Innovative Drug Discovery and Nanotechnology (Track)
Development Of New Nanoemulsions Of Dapsone For Topic Treatment Of Leprosy
Vinícius Raphael De Almeida Borges Department of Pharmaceutics
Federal University of Rio de Janeiro
Brazil
Abstract:
Leprosy is a chronic infectious disease and the drug of choice for treatment is dapsone (DAP), that also has been used for others skin disorders due its bacteriostatic and anti-inflammatory properties. However its systemic toxicity associated with oral administration reduces the applicability in skin diseases. The objective of this work is to develop and characterize a new topical nanoemulsion of dapsone. Thus, the nanotechnology was used in order to increase the solubilization. The nanoemulsions were developed as w/o systems using biocompatible excipients in accordance with the pseudo-ternary diagram obtained. The stability studies were performed during 90 days (40°C/75%RH) by the physical-chemical characterization: assay, particle size, refractive index, conductivity and pH. The in vitro release studies were carried out during 24h using Franz cells, the DAP amount was quantified by HPLC. The results confirmed the obtaining of a thermodynamically stable, isotropic and transparent w/o nanoemulsion with an efficient kinetic release of the drug (Higuchi model). It was observed that the amount of each excipient and the preparation methodology have direct impact in the performance of the formulation. The results demonstrated success in preparing new dapsone microemulsion systems for topic use of easy, inexpensive and reproducible preparation.
